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Studies link cancer, inflammatory disease
Studies link cancer, inflammatory disease
March 24 issue of Cell
The biological processes underlying diseases such as rheumatoid arthritis and cancer are fundamentally linked, and should be linked in how they are treated with drugs, a series of MIT studies indicates. Key to the work: The researchers applied an engineering approach to cell biology, using mathematical and numerical tools normally associated with the former discipline.
In a series of three papers, the latest of which appeared in the March 24 issue of Cell, Professors Douglas A. Lauffenburger, Peter K. Sorger and Michael B. Yaffe, all members of MIT's Center for Cancer Research, led a team of scientists and engineers in looking at how cells make life-or-death decisions. Understanding what tips a cell toward survival or death is key to treating diseases and fighting cancer through radiation, drug therapy and chemotherapy.
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